ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (12): 2225-2231.doi: 10.11843/j.issn.0366-6964.2017.12.001

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The Study of Influence of Environment on Transgenerational Inheritance of DNA Methylation in Mammals

GAN Mai-lin1, YANG Da-hong2, TAN Ya1,3, YANG Qiong4, PU Hong-zhou5, ZHANG Shun-hua1*, ZHU Li1*   

  1. 1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China;
    2. Mingshan District Agricultural Bureau, Ya'an 625100, China;
    3. Animal Husbandry and Veterinary Institute of Guizhou Province, Guiyang 550005, China;
    4. Chengdu Agricultural College, Chengdu 611130, China;
    5. Nanjiang County Agricultural Bureau, Bazhong 635600, China
  • Received:2017-04-10 Online:2017-12-23 Published:2017-12-23

Abstract:

Classical genetics suggests that the genetic information of the organism is determined by the genes, that is, only the change of DNA sequence can be inherited, but the epigenetic DNA modifications can't be inherited because of the cell reprograming. Recent studies have found that some of the epigenetic modification caused by environmental factors can also be passed to the offspring, and DNA methylation is one of the main mechanisms of epigenetic modification, which is a hot spot in the transgenerational inheritance field. Herein, we focus on the transgenerational inheritance of DNA methylation caused by environmental factors, which may provide some references for further study on transgenerational inheritance.

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